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In preclinical work, MOTS-c is described as interfering with the folate cycle, leading to a build-up of AICAR (an AMP analog) that switches on AMPK [1] [2]

doi: 10.5653/cerm.2022.05792 50 ZorovDBJuhaszovaMSollottSJ

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doi: 10.1016/j.sjbs.2020.12.037

Protein stimulates GLP-1 [1] and therefore can have a similar effect on appetite and body weight as GLP-1 agonists like Ozempic and Mounjaro